Consisting of 5 Chapters, this report provides a comprehensive assessment of the complex relationships between water, energy, food, and ecosystems in the Mediterranean. It covers drivers of change, cascading impacts and actionable responses to address regional challenges. The report highlights the importance of cross-sectoral collaboration, innovative solutions, and nature-based approaches to mitigate risks and enhance synergies across the WEFE components. It equips decision-makers with data-driven insights and policy evaluations to tackle climate impacts and promote sustainable resource management effectively.